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Hypothalamic thyrotropin-releasing hormone (TRH) stimulates pituitary thyrotropin (TSH) synthesis and secretion.

In turn, TSH stimulates production and release of T4 and T3 from the thyroid gland.

When enough T4 is produced, it signals to TRH and TSH that there is enough thyroid hormone in circulation and not to produce more.

About 85% of the hormone produced by our thyroid gland is T4, which is an inactive form of the hormone.

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